Keep track of Carefully (2)pentobarbital will lessen the level or outcome of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Powerful CYP3A4 inducers may well lower suvorexant efficacy; if increased suvorexant dose necessary, will not exceed twenty mg/daypentobarbital will decrease the extent or result of lon